BG-75 - ABT
Biomarker Generator produces PET Biomarkers and Radioisotopes "On Demand" and encompasses an entire PET production lab in a 300 square feet (30 sq meter) room.
It includes a self-shielded micro-cyclotron for producing the positron emitting isotopes of F-18 and C-11 and microchemistry system for labeling specific molecules with the positron emitting isotopes. The uniqueness of this system is that it is much smaller than conventional PET cyclotrons, easier to install, and simple to operate.
Low energy, positive ion radioisotope generator
| Items | Descriptions |
|---|---|
| Particle | Proton |
| Internal Beam Energy | 7.5 MeV |
| Internal Beam Current | <5 uAmps for F-18 |
| Internal Target Ports | 3 (non-simultaneous) |
| Physical Design | |
| Pole Diameter | 74.8 mm |
| Extraction Radius | 35 cm |
| Dee System | 4 |
| Dee Operating Voltage | 16 kV max |
| Frequency | 72 mHz |
| Magnetic Field | 1.2 Tesla average 1.8 Tesla max |
| Physical Dimensions | |
| Magnet Mass | 3.5 tons |
| Cyclotron Height | 0.37 m |
| Cyclotron Diameter | 1.25 m |
| Generator Shields | |
| Material Casing | 1/4" Steel |
| Shielding Material | Dense Concrete& Boronated Polyethylene |
| Diameter | 2.39 m |
| Height | 1.63 m |
| Weight | 21 tons |
| Chemistry Platform | |
| Dimensions | 81.3 x 68.6 x 101.6 cm |
| Weight | 5 tons |
| Radiation Field Room Boundary | < 1 mR/hour |
| Multiple target ports and simple F-18 target design maximizes uptime and reduces user exposure | |
| Target volume | < 300 ul |
| Target current | <5 uAmps |
| Target material | Stainless steel |
| F-18 Specification | 1 mCi per min of bombardment time |
| FDG production on demand with consumable kits, cards and embedded controls minimizes technical production staff. | |
| Final radioactivity yield | 10 – 13 mCi's |
| Final product volume | 2.0 ml |
| Control system | HMI with embedded control |
| Consumables | Reagent kits with dose synthesis cards |
Advantages
| Items | Descriptions |
|---|---|
| Simplicity | Integrated accelerator, micro-chemistry and quality control with one button operation |
| Efficiency | Economic, rapid production of individual doses of FDG |
| Small size | Easier and more cost effective installation |
| Flexibility | Capable of producing other important [18F] fluoride based research biomarkers |
| Less Radiation | Lower energy provides lower exposure to environment, public and users, and self shielding eliminates the need for mini-cell containment. |
